The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including
cell proliferation, survival, motility, and differentiation. The dysregulated activation of the …

The EGF-receptor is frequently mutated in a large variety of tumors. Here we review the most
frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase …

Androgen receptor (AR), a steroid hormone receptor, is critical for prostate cancer growth.
However, activation of AR by androgens can also lead to growth suppression and …

Purpose: Test the hypothesis that in BRAF-mutated melanomas, clinical responses to
selumetinib, a MEK inhibitor, will be restricted to tumors in which the PI3K/AKT pathway is …

A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …

The purpose of this study was to determine the role of long-chain fatty acyl-CoA synthetase 4
(ACSL4) in breast cancer. Public databases were utilized to analyze the relationship …

Increases in fatty acid metabolism have been demonstrated to promote the growth and
survival of a variety of cancers, including prostate cancer (PCa). Here, we examine the …

The human EGFR (HER) family is essential for communication between many epithelial
cancer cell types and the tumor microenvironment. Therapeutics targeting the HER family …

Background Activating mutations of the epidermal growth factor receptor (EGFR) confer
sensitivity to the tyrosine kinase inhibitors (TKi), gefitinib and erlotinib. We analysed EGFR …

The number of structures and molecular dynamics simulations of proteins is exploding
owing to dramatic advances in cryo-electron microscopy, crystallography, and computing …