The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their
regulated turnover, which is fundamental to many cellular functions. The mechanisms …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

Dilated cardiomyopathy caused by mutations in LMNA, encoding A-type lamins (ie, LMNA
cardiomyopathy), is characterized by a left ventricle enlargement and ultimately results in …

Mutations in the LMNA gene encoding Lamin A and C (Lamin A/C), major components of the
nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM), but the …

Skeletal muscles play a central role in human movement through forces transmitted by
contraction of the sarcomere. We recently showed that mammalian sarcomeres are …

Laminopathies are a group of rare disorders due to mutation in LMNA gene. Depending on
the mutation, they may affect striated muscles, adipose tissues, nerves or are multisystemic …

Abstract Asparagine (Asn, N)-linked glycosylation is an abundant post-translational
modification in which Asn, typically in N glyco-XS/T; X≠ P motifs, are modified with N …

Age-associated loss of muscle mass and function and subsequent mobility decline define
poor health outcomes, reduced quality of life, and mortality risk. The rate and extent of aging …

Precise arrangement of actin, myosin, and other regulatory components in a sarcomeric
pattern is critical for producing contractile forces in striated muscles. Actin-interacting protein …

Angiosarcoma is a rare refractory soft-tissue tumor with a poor prognosis and is treated by
radiotherapy. The fibroblast growth factor 1 (FGF1) mutant, with enhanced thermostability …