Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Cells generate mechanical forces (traction forces, TFs) while interacting with the
extracellular matrix or neighbouring cells. Forces are generated by both cells and …

T cells defend against cancer and viral infections by rapidly scanning the surface of target
cells seeking specific peptide antigens. This key process in adaptive immunity is sparked …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

Mechanochromic mechanophores are reporter molecules that indicate mechanical events
through changes of their photophysical properties. Supramolecular mechanophores in …

Extracellular matrix (ECM) rigidity serves as a crucial mechanical cue impacting diverse
biological processes. However, understanding the molecular mechanisms of rigidity sensing …

The receptor–ligand interactions in cells are dynamically regulated by modulation of the
ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates …

Dynamic manipulation of supramolecular self‐assembled structures is achieved irreversibly
or under non‐physiological conditions, thereby limiting their biomedical, environmental, and …

Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …

In the last decade, DNA-based tension sensors have made significant contributions to the
study of the importance of mechanical forces in many biological systems. Albeit successful …