Pharmacological glucocorticoids are the most prescribed anti-inflammatory medications,
and are chemical variants of cortisol, the circadian and stress hormone. Both endogenous …

Modern drug development problems are very complex and require integration of various
scientific fields. Traditionally, statistical methods have been the primary tool for design and …

Oral corticosteroid use is limited by side effects, some caused by off‐target actions on the
mineralocorticoid receptor that disrupt electrolyte balance. AZD9567 is a selective …

Aims Corticosteroids are the treatment of choice for many inflammatory diseases but often
lead to adverse effects, including hyperglycaemia. This study investigated the mechanisms …

In this work we evaluate the study design of LPS challenge experiments used for
quantification of drug induced inhibition of TNFα response and provide general guidelines of …

Unfortunately, chronic dosing of glucocorticoid receptor modulators (GRMs) is not possible
due to their numerous unwanted side effects. An area of major focus for drug discovery has …

Mathematical models based on ordinary differential equations (ODEs) are commonly used
for describing the evolution of a system over time. In drug development, pharmacokinetic …