Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities

TK Kim, EN Vandsemb, RS Herbst… - Nature Reviews Drug …, 2022 - nature.com
Tumours employ various tactics to adapt and eventually resist immune attack. These
mechanisms are collectively called adaptive immune resistance (AIR). The first defined and …

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

A Choudhury, ST Magill, CD Eaton, BC Prager… - Nature …, 2022 - nature.com
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …

Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

JL Collier, SA Weiss, KE Pauken, DR Sen… - Nature …, 2021 - nature.com
CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …

Review of functionalized nanomaterials for photothermal therapy of cancers

W Bian, Y Wang, Z Pan, N Chen, X Li… - ACS Applied Nano …, 2021 - ACS Publications
Photothermal therapy (PTT) is recognized as a promising approach for cancer theranostics
via the nonradiative conversion of light into heat energy. PTT treatment is able to reduce the …

Development of a novel combined nomogram model integrating deep learning-pathomics, radiomics and immunoscore to predict postoperative outcome of colorectal …

R Wang, W Dai, J Gong, M Huang, T Hu, H Li… - Journal of hematology & …, 2022 - Springer
Limited previous studies focused on the death and progression risk stratification of colorectal
cancer (CRC) lung metastasis patients. The aim of this study is to construct a nomogram …

The prognostic implications of tumor infiltrating lymphocytes in colorectal cancer: a systematic review and meta-analysis

GE Idos, J Kwok, N Bonthala, L Kysh, SB Gruber… - Scientific reports, 2020 - nature.com
Tumor-infiltrating lymphocytes (TILs) are an important histopathologic feature of colorectal
cancer that confer prognostic information. Previous clinical and epidemiologic studies have …

Molecular mechanisms linking exercise to cancer prevention and treatment

P Hojman, J Gehl, JF Christensen, BK Pedersen - Cell metabolism, 2018 - cell.com
The benefits of exercise training for cancer patients are becoming increasingly evident.
Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth …

Cell motility in cancer invasion and metastasis: insights from simple model organisms

CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

CD8 T cell score as a prognostic biomarker for triple negative breast cancer

M Oshi, M Asaoka, Y Tokumaru, L Yan… - International journal of …, 2020 - mdpi.com
CD8 T cell is an essential component of tumor-infiltrating lymphocytes (TIL) and tumor
immune microenvironment (TIME). Using the xCell CD8 T cell score of whole tumor gene …