[HTML][HTML] LCAT-targeted therapies: Progress, failures and future

K Yang, J Wang, H Xiang, P Ding, T Wu, G Ji - Biomedicine & …, 2022 - Elsevier
Lecithin: cholesterol acyltransferase (LCAT) is the only enzyme in plasma which is able to
esterify cholesterol and boost cholesterol esterify with phospholipid-derived acyl chains. In …

Plaque calcification: do lipoproteins have a role?

EJ Akers, SJ Nicholls, BA Di Bartolo - … , thrombosis, and vascular …, 2019 - Am Heart Assoc
Vascular calcification (VC) is strongly associated with all-cause mortality and is an
independent predictor of cardiovascular events. Resulting from its complex, multifaceted …

High-density lipoproteins: A promising tool against cancer

A Ossoli, A Wolska, AT Remaley… - Biochimica et Biophysica …, 2022 - Elsevier
High-density lipoproteins (HDL) are well known for their protective role against the
development and progression of atherosclerosis. Atheroprotection is mainly due to the key …

Fargesin alleviates atherosclerosis by promoting reverse cholesterol transport and reducing inflammatory response

G Wang, JH Gao, LH He, XH Yu, ZW Zhao, J Zou… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Background and aims Fargesin mainly functions in the improvement of lipid metabolism and
the inhibition of inflammation, but the role of fargesin in atherogenesis and the molecular …

Connection between the Altered HDL Antioxidant and Anti‐Inflammatory Properties and the Risk to Develop Alzheimer's Disease: A Narrative Review

F Zimetti, MP Adorni, J Marsillach… - Oxidative medicine …, 2021 - Wiley Online Library
The protein composition of high‐density lipoprotein (HDL) is extremely fluid. The quantity
and quality of protein constituents drive the multiple biological functions of these …

Air pollution: another threat to HDL function

A Ossoli, F Cetti, M Gomaraschi - International Journal of Molecular …, 2022 - mdpi.com
Epidemiological studies have consistently demonstrated a positive association between
exposure to air pollutants and the incidence of cardiovascular disease, with the strongest …

High-density lipoproteins and the kidney

A Strazzella, A Ossoli, L Calabresi - Cells, 2021 - mdpi.com
Dyslipidemia is a typical trait of patients with chronic kidney disease (CKD) and it is typically
characterized by reduced high-density lipoprotein (HDL)-cholesterol (c) levels. The low HDL …

Current and emerging reconstituted HDL-apoA-I and HDL-apoE approaches to treat atherosclerosis

EK Valanti, K Dalakoura-Karagkouni… - Journal of personalized …, 2018 - mdpi.com
Atherosclerosis affects millions of people worldwide. However, the wide variety of limitations
in the current therapeutic options leaves much to be desired in future lipid-lowering …

[HTML][HTML] HDL and chronic kidney disease

C Pavanello, A Ossoli - Atherosclerosis Plus, 2023 - Elsevier
Abstract Low HDL-cholesterol (HDL-C) concentrations are a typical trait of the dyslipidemia
associated with chronic kidney disease (CKD). In this condition, plasma HDLs are …

Associations between myeloperoxidase and paraoxonase-1 and type 2 diabetes in patients with ischemic heart disease

K Nessler, R Grzybczak, M Nessler, J Zalewski… - BMC Cardiovascular …, 2022 - Springer
Background The phrase “dysfunctional high-density lipoprotein” has been developed in the
literature to describe the particle which loses its basic role-anti-oxidative and anti …