Our current understanding of the mechanisms of action of antitumor agents and the precise
mechanisms underlying drug resistance is that these two processes are directly linked …

Ovarian cancer is the most deadly gynecologic malignancy, and its incidence is gradually
increasing. Despite improvements after treatment, the results are unsatisfactory and survival …

Aim Pemetrexed, a new generation antifolate drug, has been approved for the treatment of
locally advanced or metastatic breast cancer. However, factors affecting its efficacy and …

Drug–target interaction, cellular internalization, and target engagement should be
addressed to design a lead with high chances of success in further optimization stages …

Introduction Thymidylate synthase (TS) plays a crucial role in cellular growth, proliferation,
DNA synthesis, and repair, thus gaining attention for targeted therapies in cancer. TS …

Autoimmune hepatitis (AIH), characterized by immune-driven liver destruction and cytokine
production, is a progressive inflammatory liver condition that may progress to hepatic …

Human thymidylate synthase (hTS) has an important role in DNA biosynthesis, thus it is
essential for cell survival. TS is involved in the folate pathways, specifically in the de novo …

Purpose To evaluate the potential effects of PEGylated pH-sensitive liposomes on the
intracellular activity of a new peptide recently characterized as a novel inhibitor of the human …

Abstract Recently, octapeptide LSCQLYQR (LRp), reducing growth of cis-platinum (cDDP)
resistant ovarian carcinoma cells by inhibiting the monomer–monomer interface of the …

Background Several serum biomarkers, including miRNA, mRNA, protein and peptides in
cancer patients are also important mediators of cancer progression. Methods The …