Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …

HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …

Glial cells and neurons are engaged in a continuous and highly regulated bidirectional
dialog. A remarkable example is the control of myelination. Oligodendrocytes in the central …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …

Cancer treatment suffers from limitations that have a major impact on the patient's quality of
life and survival. In the case of chemotherapy, the systemic distribution of cytotoxic drugs …

Highlights•Secreted signals regulate OPC specification during development and in the
adult.•OL differentiation is controlled by chromatin remodeling and transcription …