Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial
tree, although the extent to which this occurs can vary among conditions. The multiple …

Multiple breath inert gas washout (MBW) is a lung function technique to measure ventilation
inhomogeneity. The technique was developed more than 60 years ago, but not much used …

Background Comparability of multiple breath washout (MBW) systems has been little
explored. We assessed agreement in lung clearance index (LCI) from two similar …

Rationale: Asthma is often characterised by inflammation, damage and dysfunction of the
small airways, but no standardised biomarkers are available. Objectives: Using a novel …

Background Lung clearance index (LCI), a marker of ventilation inhomogeneity, is elevated
early in children with cystic fibrosis (CF). However, in infants with CF, LCI values are found to …

Background: Lung clearance index (LCI) is becoming recognized as an important addition in
the monitoring of pediatric cystic fibrosis (CF). The non-invasive technique is easy to perform …

Background and Objectives Multiple-breath washout (MBW) is an attractive test to assess
ventilation inhomogeneity, a marker of peripheral lung disease. Standardization of MBW is …

Functional residual capacity (FRC) accuracy is essential for deriving multiple-breath
nitrogen washout (MBNW) indices, and is the basis for device validation. Few studies have …

Background The Innocor device contains a highly sensitive photoacoustic gas analyser that
has been used to perform multiple breath washout (MBW) measurements using very low …

Ventilation heterogeneity is frequent in bronchial asthma and can be assessed using
multiple breath wash-out testing (MBW). Most data is available in paediatric patients and …