The brain processes information by transmitting signals at synapses, which connect neurons
into vast networks of communicating cells. In these networks, synapses not only transmit …

How can the genome of Drosophila melanogaster contain fewer genes than the
undoubtedly simpler organism Caenorhabditis elegans? The answer must lie within their …

Syntaxin 1, an essential protein in synaptic membrane fusion, contains a helical
autonomously folded N‐terminal domain, a C‐terminal SNARE motif and a transmembrane …

Neurexins are a large family of proteins that act as neuronal cell-surface receptors. The
function and localization of the various neurexins, however, have not yet been clarified. Beta …

The G protein‐coupled receptor (GPCR) Proteolysis Site (GPS) of cell‐adhesion GPCRs
and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis …

Rapid conduction in myelinated axons depends on the generation of specialized subcellular
domains to which different sets of ion channels are localized. Here, we describe the …

Neurexins are essential presynaptic cell adhesion molecules that are linked to
schizophrenia and autism and are subject to extensive alternative splicing. Here, we used a …

In nonneuronal cells, the cell surface protein dystroglycan links the intracellular cytoskeleton
(via dystrophin or utrophin) to the extracellular matrix (via laminin, agrin, or perlecan) …

Neurexins are neuron-specific vertebrate proteins with hundreds of differentially spliced
isoforms that may function in synapse organization. We now show that Drosophila …

Spider venoms represent an incredible source of biologically active substances which
selectively target a variety of vital physiological functions in both insects and mammals …