Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …

SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys,
the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial …

Elevated serum urate levels can cause gout, an excruciating disease with suboptimal
treatment. Previous GWAS identified common variants with modest effects on serum urate …

An edible sea cucumber Holothuria atra has been hypothesized to have medicinal benefits
against hyperuricemia owing to its bioactive compounds, including mono-and poly …

Chronic gouty arthritis, caused by a persistent increase in, and the deposition of, soluble uric
acid (sUA), can induce pathological chondrocyte destruction; however, the effects of urate …

The nuclear factor E2-related factor 2 (NRF2) signaling pathway is one of the most important
cell defense pathways. However, it is unclear whether genetic variants in NRF2 signaling …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality
worldwide. Although the mechanisms of HCC progression are not well understood, recent …

Xenopus laevis oocytes are a useful heterologous expression system for expressing
glucose transporters (GLUTs) and examining their functions. In this chapter, we provide a …

Objective This study is aimed to describe the clinical and genetic characteristics of a
Chinese woman diagnosed with renal hypouricemia type 2 (RHUC2). We also summarize …

Transportér GLUT9, kódovaný genem SLC2A9, je jedním z klíčových proteinů zajišťujících
přenos kyseliny močové přes membránu epiteliálních buněk proximálního tubulu člověka …