Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

The Th2 cytokines, interleukin (IL)-4 and-13, are structurally and functionally related. They
regulate immune responses and the immune microenvironment, not only under normal …

Background The macrophage, one of the several key immune cell types, is believed to be
involved in tumorigenesis. However, the mechanism of macrophages promoting tumor …

Abstract IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different
cell types and responsible for a broad range of biology and functions. Physiologically, Th2 …

Purpose: Cancer-associated fibroblasts (CAF) are essential components of the stroma that
play a critical role in cancer progression. This study aimed to identify novel CAFs markers …

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2, CD213A), a high-affinity membrane
receptor of the anti-inflammatory Th2 cytokine IL-13, is overexpressed in a variety of solid …

Abstract Interleukin 13 receptor alpha 2 (IL13Rα2) is increasingly recognized as a relevant
player in cancer invasion and metastasis. Despite being initially considered a decoy …

The most suitable strategy to improving the long-term viability of cancer patients and
overcoming the high morbidity and severity of cancer is the precise identification of particular …

A major challenge for successful immunotherapy against glioma is the identification and
characterization of validated targets. We have taken a bioinformatics approach towards …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …