Every day thousands of surgical procedures are performed to replace or repair tissue that
has been damaged through disease or trauma. The developing field of tissue engineering …

Complications in treatment of large bone defects using bone grafting still remain. Our
understanding of the endogenous bone regeneration cascade has inspired the exploration …

Gene therapy involves the introduction of foreign genetic material into cells in order exert a
therapeutic effect. The application of gene therapy to the field of orthopaedic tissue …

The clinical translation of bioactive scaffolds for the treatment of large segmental bone
defects has remained a challenge due to safety and efficacy concerns as well as prohibitive …

The perspective of an innovative new concept integrating tissue-engineering techniques
with an established surgical technique is described. The focus is primarily on a one-step …

Periosteum has been demonstrated to contain mesenchymal progenitor cells differentiating
to osteoblasts, and both bone morphogenetic protein-2 (BMP-2) and vascular endothelial …

Repair of deep burn by use of the dermal equivalent relies strongly on the angiogenesis and
thereby the regeneration of dermis. To enhance the dermal regeneration, in this study …

Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic
strategy. Among its advantages over protein delivery are the potential for directed, sustained …

Mesenchymal stem cells (MSCs) can be isolated from several tissues in the body, have the
ability to selfrenewal, show immune suppressive properties and are multipotent, being able …

As well as acting to fill defects and allow for cell infiltration and proliferation in regenerative
medicine, biomaterial scaffolds can also act as carriers for therapeutics, further enhancing …