Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery

M Ashrafizadeh, A Zarrabi, S Mirzaei, F Hashemi… - Food and Chemical …, 2021 - Elsevier
Cancer is the second leading cause of death worldwide. Majority of recent research efforts in
the field aim to address why cancer resistance to therapy develops and how to overcome or …

Polyphenols mediate neuroprotection in cerebral ischemic stroke—an update

SA Abdelsalam, K Renu, HA Zahra, BM Abdallah… - Nutrients, 2023 - mdpi.com
Stroke is one of the main causes of mortality and disability, and it is due to be included in
monetary implications on wellbeing frameworks around the world. Ischemic stroke is caused …

Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney …

SE Owumi, AI Kazeem, B Wu, LO Ishokare… - Scientific reports, 2022 - nature.com
Sorghum bicolor plant has a high abundance of 3-deoxyanthocyanins, flavonoids and other
polyphenol compounds that have been shown to offer numerous health benefits …

Polymeric scaffold of Gallic acid loaded chitosan nanoparticles infused with collagen-fibrin for wound dressing application

PS Kaparekar, S Pathmanapan… - International Journal of …, 2020 - Elsevier
The present study explores the curative efficacy of collagen-fibrin scaffold with Gallic acid
loaded Chitosan nanoparticles (GA-CSNPs) in wound healing. GA-CSNPs were …

Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis

SE Owumi, DO Lewu, UO Arunsi… - Human & experimental …, 2021 - journals.sagepub.com
Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use.
Luteolin is a polyphenolic phytochemical that exhibits beneficial biological effects via …

Rutin ameliorates copper sulfate‐induced brain damage via antioxidative and anti‐inflammatory activities in rats

J Arowoogun, OO Akanni, AO Adefisan… - … of Biochemical and …, 2021 - Wiley Online Library
Abstract Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect
health outcomes. We investigated the protective role of rutin on Cu‐induced brain damage …

Gallic acid protects against Aflatoxin B1‐induced oxidative and inflammatory stress damage in rats kidneys and liver

S Owumi, ES Najophe, EO Farombi… - Journal of food …, 2020 - Wiley Online Library
The adverse effect of Aflatoxin B1 (AFB1) exposure in both humans and rodents has been
widely reported. The beneficial health effects of gallic acid (GA) against AFB1‐induced …

Caffeic acid mitigates aflatoxin B1‐mediated toxicity in the male rat reproductive system by modulating inflammatory and apoptotic responses, testicular function, and …

SE Owumi, CE Irozuru, UO Arunsi… - Journal of food …, 2022 - Wiley Online Library
Abstract Aflatoxin B1 (AFB1) is a toxic metabolite of public health concern. The present study
investigates the protective effects of caffeic acid (CA) against AFB1‐induced oxidative stress …

The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions

D Gandhi, AP Rudrashetti… - Journal of Applied …, 2022 - Wiley Online Library
Manganese (Mn) is an essential trace element for humans, but long‐term environmental or
occupational exposures can lead to numerous health problems. Although many studies …

Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

SE Owumi, SO Nwozo, UO Arunsi, AK Oyelere… - Toxicology and applied …, 2021 - Elsevier
Doxorubicin (DOX), is a drug against lung malignancies with undesirable side effect
including oxidative, inflammatory and apoptotic effects. Luteolin (LUT), present in fruits and …