Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Arthritis, including osteoarthritis (OA) and rheumatoid arthritis (RA), is the leading cause of
years lived with disability (YLD) worldwide. Although pain is the cardinal symptom of …

Rheumatoid arthritis (RA) is a debilitating systemic disease characterized by joint
inflammation (edema and synovitis), fatigue, and joint pain. If left untreated, the disease …

Chronic pain can develop in response to conditions such as inflammatory arthritis. The
central mechanisms underlying the development and maintenance of chronic pain in …

Aims This study aimed to determine whether pathological changes in the bone marrow
cause Osteoarthritis (OA) pain based on magnetic resonance imaging (MRI) …

Pain is a dominant symptom of rheumatoid arthritis (RA) and its adequate treatment
represents a major unmet need. However, the cellular mechanisms that drive arthritis pain …

Synovitis contributes to temporomandibular joint (TMJ) pain, nevertheless, the detailed
nociceptive mechanism remains unclear. In this study, a rat model of TMJ synovitis was …

Nerve terminals within the tumor microenvironment as potential pain-mitigating targets for
local infiltration analgesia is relatively less explored. In this study, we examine the role of key …

Upon transient musculoskeletal diseases, some patients develop persistent pain while
others recover from pain. Here, we studied whether such heterogeneity also occurs in rats …

Visceral hypersensitivity (VH) is the predominant pathogenesis of functional dyspepsia (FD).
Duodenal hypersensitivity along with nausea further reduces the comfort level in gastric …