M Conti - Molecular endocrinology, 2000 - academic.oup.com
The discovery of cyclic nucleotides as second messengers has paved the way to much of what we know about signal transduction and the mechanisms of hormone action. Even …
J Beavo, SH Francis, MD Houslay - 2007 - api.taylorfrancis.com
The establishment of a Gordon Research Conference devoted to cyclic nucleotide phosphodiesterases has had an enormous impact on the field by facilitating collaborations …
AM Laties, E Zrenner - Progress in Retinal and Eye Research, 2002 - Elsevier
Viagra®(sildenafil citrate) improves penile erections in men with erectile dysfunction (ED) by selectively inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), which is present in …
purpose. Phosphodiesterase (PDE) inhibitors are important therapeutic agents, but their effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. The …
KM Manoj, H Tamagawa, N Bazhin… - Journal of Cellular …, 2022 - Wiley Online Library
The classical paradigm of visual physiology comprises of the following features:(i) rod/cone cells located at the rear end of the retina serve as the primary transducers of incoming photo …
IM Pepe - Progress in retinal and eye research, 2001 - Elsevier
The present models of phototransduction for vertebrates and invertebrates have been reviewed and the relative literature updated. The emerging picture for vertebrate …
K Sakamoto, M McCluskey, TG Wensel… - Human molecular …, 2009 - academic.oup.com
The heterotetrameric phosphodiesterase (PDE) 6 complex, made up of α, β and two γ subunits, regulates intracellular cGMP levels by hydrolyzing cGMP in response to light …
X Zeng-Elmore, XZ Gao, R Pellarin… - Journal of molecular …, 2014 - Elsevier
Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation pathway in rod and cone photoreceptors. Its tight regulation is essential for the speed …
B Barren, L Gakhar, H Muradov, KK Boyd… - The EMBO …, 2009 - embopress.org
The inhibitory interaction of phosphodiesterase‐6 (PDE6) with its γ‐subunit (Pγ) is pivotal in vertebrate phototransduction. Here, crystal structures of a chimaeric PDE5/PDE6 catalytic …