Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …

The discovery of cyclic nucleotides as second messengers has paved the way to much of
what we know about signal transduction and the mechanisms of hormone action. Even …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Viagra®(sildenafil citrate) improves penile erections in men with erectile dysfunction (ED) by
selectively inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), which is present in …

purpose. Phosphodiesterase (PDE) inhibitors are important therapeutic agents, but their
effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. The …

The classical paradigm of visual physiology comprises of the following features:(i) rod/cone
cells located at the rear end of the retina serve as the primary transducers of incoming photo …

The present models of phototransduction for vertebrates and invertebrates have been
reviewed and the relative literature updated. The emerging picture for vertebrate …

The heterotetrameric phosphodiesterase (PDE) 6 complex, made up of α, β and two γ
subunits, regulates intracellular cGMP levels by hydrolyzing cGMP in response to light …

Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation
pathway in rod and cone photoreceptors. Its tight regulation is essential for the speed …

The inhibitory interaction of phosphodiesterase‐6 (PDE6) with its γ‐subunit (Pγ) is pivotal in
vertebrate phototransduction. Here, crystal structures of a chimaeric PDE5/PDE6 catalytic …