Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that
occurs during development and is essential for shaping embryos. Also implicated in cancer …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults that affects the
myeloid lineage. The recent advances have upgraded our understanding of the cytogenetic …

The epicardial epithelial-mesenchymal transition (EMT) is hypothesized to generate
cardiovascular progenitor cells that differentiate into various cell types, including coronary …

Angiogenesis is regulated by the balance of proangiogenic VEGF 165 and antiangiogenic
VEGF 165 b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor gene, suppress …

Rationale: Cardiac fibroblasts are critical to proper heart function through multiple
interactions with the myocardial compartment, but appreciation of their contribution has …

CD19-directed chimeric antigen receptor (CAR) T cells are clinically effective in a limited set
of leukemia patients. However, CAR T-cell therapy thus far has been largely restricted to …

In the past decade, the emergence of chimeric antigen receptor (CAR) T-cell therapy has led
to a cellular immunotherapy revolution against various cancers. Although CAR-T cell …

Objective We found that carbonic anhydrase IV (CA4), a member of the carbonic
anhydrases, is silenced in colorectal cancer (CRC). We analysed its epigenetic inactivation …

Signals mediated by the chemokine CXCL12 and its receptor CXCR4 are involved in the
progression of ovarian cancer through enhancement of tumor angiogenesis and …

The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …