The accumulation of misfolded proteins in the human brain is one of the critical features of
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …

Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and
their aggregates by protein quality control (PQC), of which molecular chaperones are an …

While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei
into complex droplets (anisosomes) comprised of TDP-43-containing liquid outer shells and …

Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to
play an important role in neurodegenerative disorders, including Alzheimer's and …

Huntington's disease (HD) is an incurable neurodegenerative disease characterized by
abnormal motor movements, personality changes, and early death. HD is caused by a …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …

Huntington's disease (HD) is the most common inherited neurodegenerative disease and is
characterized by uncontrolled excessive motor movements and cognitive and emotional …

Currently available therapies for adult onset neurodegenerative diseases provide
symptomatic relief but do not modify disease progression. Here we explore a new …

Heat shock proteins (HSPs) are induced in response to many injuries including stroke,
neurodegenerative disease, epilepsy, and trauma. The overexpression of one HSP in …

Hsp90 is a molecular chaperone with important roles in regulating pathogenic
transformation. In addition to its well-characterized functions in malignancy, recent evidence …