Recent progress and perspectives on neural chip platforms integrating PDMS-based microfluidic devices and microelectrode arrays

S Xu, Y Liu, Y Yang, K Zhang, W Liang, Z Xu, Y Wu… - Micromachines, 2023 - mdpi.com
Recent years have witnessed a spurt of progress in the application of the encoding and
decoding of neural activities to drug screening, diseases diagnosis, and brain–computer …

Living-neuron-based autogenerator

SA Gerasimova, A Beltyukova, A Fedulina, M Matveeva… - Sensors, 2023 - mdpi.com
We present a novel closed-loop system designed to integrate biological and artificial
neurons of the oscillatory type into a unified circuit. The system comprises an electronic …

Structure-function dynamics of engineered, modular neuronal networks with controllable afferent-efferent connectivity

N Winter-Hjelm, ÅB Tomren, P Sikorski… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. Microfluidic devices interfaced with microelectrode arrays have in recent years
emerged as powerful platforms for studying and manipulating in vitro neuronal networks at …

Spatial computing in modular spiking neural networks with a robotic embodiment

SA Lobov, AN Mikhaylov, ES Berdnikova, VA Makarov… - Mathematics, 2023 - mdpi.com
One of the challenges in modern neuroscience is creating a brain-on-a-chip. Such a
semiartificial device based on neural networks grown in vitro should interact with the …

Portrait of intense communications within microfluidic neural networks

V Dupuit, A Briançon-Marjollet, C Delacour - Scientific Reports, 2023 - nature.com
In vitro model networks could provide cellular models of physiological relevance to
reproduce and investigate the basic function of neural circuits on a chip in the laboratory …

The Profile of Network Spontaneous Activity and Functional Organization Interplay in Hierarchically Connected Modular Neural Networks In Vitro

Y Pigareva, A Gladkov, V Kolpakov, VB Kazantsev… - Micromachines, 2024 - mdpi.com
Modern microtechnology methods are widely used to create neural networks on a chip with
a connection architecture demonstrating properties of modularity and hierarchy similar to …

Microfluidic bi-layer platform to study functional interaction between co-cultured neural networks with unidirectional synaptic connectivity

Y Pigareva, A Gladkov, V Kolpakov, A Bukatin, S Li… - Micromachines, 2023 - mdpi.com
The complex synaptic connectivity architecture of neuronal networks underlies cognition and
brain function. However, studying the spiking activity propagation and processing in …

Spatial computing in structured spiking neural networks with a robotic embodiment

SA Lobov, AN Mikhaylov, ES Berdnikova… - arXiv preprint arXiv …, 2021 - arxiv.org
One of the challenges of modern neuroscience is creating a" living computer" based on
neural networks grown in vitro. Such an artificial device is supposed to perform …

Neurons as biosensors for discriminating neurological disorders in a brain-on-chip platform: Application to Alzheimer s Disease using patient CSF

L Miny, J Rontard, A Allouche, N Violle, L Dubuisson… - bioRxiv, 2024 - biorxiv.org
Alzheimer s disease (AD) is characterized by the accumulation of aggregated amyloid beta
peptide (Aβ) leading to progressive neuronal loss and dysfunction. Current AD diagnosis …

[HTML][HTML] Integration of Immature Neurons Maintain Unidirectional Connectivity of Pre-Existed Network In Vitro

VN Kolpakov, MS Zemlyanskov… - Opera Medica et …, 2022 - cyberleninka.ru
Recovery of the neural networks after brain injury can be studied in vitro using cell
patterning technologies such as microfluidics. In this study, neural tissue recovery of cortical …