Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …

Severe socioeconomic deprivation (SED) and adverse childhood experiences (ACE) are
significantly associated with the development in adulthood of (i) enhanced inflammatory …

Exposure of a developing foetus to maternal gestational diabetes (GDM) has been shown to
programme future risk of diabetes and obesity. Epigenetic variation in foetal tissue may have …

Abstract Children conceived using Assisted Reproductive Technologies (ART) have a
higher incidence of growth and birth defects, attributable in part to epigenetic perturbations …

STUDY QUESTION Do assisted reproductive technologies alter DNA methylation and/or
transcription of transposable elements and imprinted genes in cord blood and placenta …

This review provides an overview of the unique features of DNA methylation in the human
placenta. We discuss the importance of understanding placental development, structure …

Inherent genetic programming and environmental factors affect fetal growth in utero.
Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or …

Introduction The aim of this study is to determine whether the gene expression and
associated DNA methylation regulation of H19 and IGF2 are altered in placentas conceived …

Background Studies have recently examined the role of epigenetic mechanisms in
preeclampsia pathophysiology. One commonly examined epigenetic process is DNA …

Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …