Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Osteocalcin (OC) is a non‐collagenous, vitamin K‐dependent protein secreted in the late
stage of osteoblasts differentiation. The presence of the three residues of γ …

We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

Targeted disruption of core binding factor α1 (Cbfa1) showed that Cbfa1 is an essential
transcription factor in osteoblast differentiation and bone formation. Furthermore, both in vitro …

Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and
inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …

We present an overview of the concepts of tissue-specific transcriptional control
mechanisms essential for development of the bone cell phenotype. BMP2 induced …

Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

Abstract The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9
(MMP9) are key regulators of growth plate maturation and bone formation. The genes for …

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes that
have been implicated in the regulation of gene expression, cell-cycle control and …

Bone remodeling is central to maintaining the integrity of the skeletal system, wherein the
developed bone is constantly renewed by the balanced action of osteoblastic bone …