A Neve, A Corrado, FP Cantatore - Journal of cellular …, 2013 - Wiley Online Library
Osteocalcin (OC) is a non‐collagenous, vitamin K‐dependent protein secreted in the late stage of osteoblasts differentiation. The presence of the three residues of γ …
GS Stein, JB Lian, AJ Van Wijnen, JL Stein… - Oncogene, 2004 - nature.com
We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
W Liu, S Toyosawa, T Furuichi, N Kanatani… - The Journal of cell …, 2001 - rupress.org
Targeted disruption of core binding factor α1 (Cbfa1) showed that Cbfa1 is an essential transcription factor in osteoblast differentiation and bone formation. Furthermore, both in vitro …
SK Zaidi, AJ Sullivan, R Medina, Y Ito… - The EMBO …, 2004 - embopress.org
Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …
JB Lian, GS Stein, A Javed, AJ Van Wijnen… - Reviews in Endocrine …, 2006 - Springer
We present an overview of the concepts of tissue-specific transcriptional control mechanisms essential for development of the bone cell phenotype. BMP2 induced …
JB Lian, A Javed, SK Zaidi, C Lengner… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone in the adult involve an exquisite interplay of developmental cues, signaling proteins …
J Pratap, A Javed, LR Languino… - … and cellular biology, 2005 - Am Soc Microbiol
Abstract The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9 (MMP9) are key regulators of growth plate maturation and bone formation. The genes for …
IL de la Serna, KA Carlson, AN Imbalzano - Nature genetics, 2001 - nature.com
Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes that have been implicated in the regulation of gene expression, cell-cycle control and …
S Kim, T Koga, M Isobe, BE Kern… - Genes & …, 2003 - genesdev.cshlp.org
Bone remodeling is central to maintaining the integrity of the skeletal system, wherein the developed bone is constantly renewed by the balanced action of osteoblastic bone …