Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

ATP-binding cassette (ABC) transporters are membrane-spanning proteins involved in
cholesterol homeostasis, transport of various molecules in and out of cells and organelles …

This review summarized the current breakthroughs in the chemistry of acridines as anti-
cancer agents, including new structural and biologically active acridine attributes. Acridine …

Cancer-associated fibroblasts (CAFs) are one of the highly abundant components in the
tumor microenvironment (TME). They secrete several cytokines, which amplified tumor …

Background Breast cancer stem cells (BCSCs) have a critical role in progression of breast
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …

Objective Sensitization of mismatch repair (MMR)-deficient colorectal cancer (CRC) cells by
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …

Accumulating evidence has demonstrated that cancer stem cells (CSCs) play an essential
role in tumor progression and reoccurrence and drug resistance. Multiple signaling …

Innovation in biomedical science is always a field of interest for researchers. Drug delivery,
being one of the key areas of biomedical science, has gained considerable significance …

Background Breast cancer is the most prevalent cancer worldwide, with high morbidity and
mortality. Despite great advances in the therapeutic strategies, the survival rate in the past …

As a multifactorial disease, treatment of cancer depends on understanding unique
mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for …