A surrogate endpoint is intended to replace a clinical endpoint for the evaluation of new
treatments when it can be measured more cheaply, more conveniently, more frequently, or …

Meta-analysis is the application of statistics to combine results from multiple studies and
draw appropriate inferences. Its use and importance have exploded over the last 25 years …

Purpose To coordinate humanitarian organisations with different mandates that flock the
scenes of disasters to save lives and respond to varied needs arising from the increased …

The use of surrogate outcomes that predict treatment effect on an unobserved true outcome
may have substantial economic and ethical advantages, through reducing the length and …

Applied Surrogate Endpoint Evaluation Methods with SAS and R Page 1 Page 2 Ariel Alonso
Theophile Bigirumurame Tomasz Burzykowski Marc Buyse Geert Molenberghs Leacky …

The increasing cost of drug development has raised the demand for surrogate endpoints
when evaluating new drugs in clinical trials. However, over the years, it has become clear …

The last 20 years have seen lots of work in the area of surrogate marker validation, partly
devoted to frame the evaluation in a multitrial framework, leading to definitions in terms of …

The occurrence of negative variance components is a reasonably well understood
phenomenon in the case of linear models for hierarchical data, such as variance-component …

This study explores the implementation of the analytic hierarchy process in usability
evaluations, specifically focusing on user interface assessment during software …

For a number of reasons, surrogate endpoints are considered instead of the so-called true
endpoint in clinical studies, especially when such endpoints can be measured earlier …