Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

Hepatocarcinogenesis is a slow process during which genomic changes progressively alter
the hepatocellular phenotype to produce cellular intermediates that evolve into …

Recurrent chromosomal aberrations are often observed in hepatocellular carcinoma (HCC),
but little is known about the functional non-coding sequences, particularly microRNAs …

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading
cause of cancer death worldwide. Despite recent advances in the diagnosis and treatment of …

Numerous genetic alterations are accumulated during the process of hepatocarcinogenesis.
These genetic alterations can be divided into two groups. The first set of genetic alterations …

The p16 INK4a and p14 ARF tumor suppressor genes (TSGs) are encoded within the
CDKN2A locus on chromosome 9p21 and function as cell cycle regulatory proteins in the …

Through a genome-wide cDNA microarray, we identified that the paternally expressed gene
10 (PEG10) was highly expressed in a great majority of hepatocellular carcinomas, although …

Hepatocarcinogenesis is a multistep process developing from normal through chronic
hepatitis and cirrhosis to HCC. With advances in molecular technology, there is a growing …

E-cadherin is a key cell adhesion protein implicated as a tumor/invasion suppressor in
human carcinomas and a binding partner of β-catenin, which plays a critical role in Wnt …

EHMT2 is a histone lysine methyltransferase localized in euchromatin regions and acting as
a corepressor for specific transcription factors. Although the role of EHMT2 in transcriptional …