Impact of the Human Cell Atlas on medicine

JE Rood, A Maartens, A Hupalowska, SA Teichmann… - Nature medicine, 2022 - nature.com
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

Advances in data‐independent acquisition mass spectrometry towards comprehensive digital proteome landscape

RB Kitata, JC Yang, YJ Chen - Mass spectrometry reviews, 2023 - Wiley Online Library
The data‐independent acquisition mass spectrometry (DIA‐MS) has rapidly evolved as a
powerful alternative for highly reproducible proteome profiling with a unique strength of …

The 2022 report on the human proteome from the HUPO human proteome project

GS Omenn, L Lane, CM Overall, C Pineau… - Journal of proteome …, 2022 - ACS Publications
The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP)
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …

Anatomical structures, cell types and biomarkers of the Human Reference Atlas

K Börner, SA Teichmann, EM Quardokus, JC Gee… - Nature cell …, 2021 - nature.com
Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …

[HTML][HTML] Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

N Alkon, WM Bauer, T Krausgruber, I Goh… - Journal of Allergy and …, 2022 - Elsevier
Background Although ample knowledge exists about phenotype and function of cutaneous T
lymphocytes, much less is known about the lymphocytic components of the skin's innate …

[HTML][HTML] Flavonoids as promising natural compounds in the prevention and treatment of selected skin diseases

B Čižmárová, B Hubková, V Tomečková… - International Journal of …, 2023 - mdpi.com
Phytochemicals represent a large and diverse group of naturally occurring compounds,
bioactive nutrients, or phytonutrients produced by plants, widely found in fruits, vegetables …

Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth

J Li, J Ma, Q Zhang, H Gong, D Gao, Y Wang… - Nature …, 2022 - nature.com
Human skin comprises stratified squamous epithelium and dermis with various stromal cells
and the extracellular matrix (ECM). The basement membrane (BM), a thin layer at the top of …

β-Glucan extracts as high-value multifunctional ingredients for skin health: A review

P Sousa, D Tavares-Valente, M Amorim… - Carbohydrate …, 2023 - Elsevier
Abstract β-Glucans, which are naturally present in cereals, yeast, and mushrooms, have
gained attention as a potential natural source for functional foods and pharmaceuticals. Due …

3D reconstruction of skin and spatial mapping of immune cell density, vascular distance and effects of sun exposure and aging

S Ghose, Y Ju, E McDonough, J Ho… - Communications …, 2023 - nature.com
Mapping the human body at single cell resolution in three dimensions (3D) is important for
understanding cellular interactions in context of tissue and organ organization. 2D spatial …

Therapeutic potential of targeting interleukin‐1 family cytokines in chronic inflammatory skin diseases

L Calabrese, Z Fiocco, TK Satoh… - British Journal of …, 2022 - academic.oup.com
Summary The interleukin (IL)‐1 family of cytokines is a central regulator of a myriad of
immunological responses. It comprises several cytokines, including those belonging to the …