The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …

Although pigs are used widely as models of human disease, their utility as models has been
enhanced by genetic engineering. Initially, transgenes were added randomly to the genome …

Current understanding of the complex process of wound repair is based on decades of
study. Integral to this understanding has been the use of in vitro and in vivo models to …

We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC)
gene (APC) that are orthologous to those responsible for human familial adenomatous …

Increasing incidence of neurodegenerative disorders such as Alzheimer's disease and
Parkinson's disease has become one of the most challenging health issues in ageing …

Mutations in the insulin (INS) gene may cause permanent neonatal diabetes mellitus
(PNDM). Ins2 mutant mouse models provided important insights into the disease …

During the last two decades, pigs have been used to develop some of the most important
large animal models for biomedical research. Advances in pig genome research, genetic …

Background Somatic cell nuclear transfer (SCNT) using genetically engineered donor cells
is currently the most widely used strategy to generate tailored pig models for biomedical …