The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the
extracellular matrix. These proteinases play a central role in many biological processes …

▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian
metamorphosis, yet they have attracted more attention because of their roles in disease …

Tissue inhibitors of metalloproteinases (TIMPs) are the major cellular inhibitors of the matrix
metalloproteinase (MMP) sub-family, exhibiting varying efficacy against different members …

Matrix metalloproteinases (MMPs) are endopeptidases that contribute to growth,
development and wound healing as well as to pathologies such as arthritis and cancer. Until …

Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …

Matrix metalloproteinases (MMPs) are now acknowledged as key players in the regulation of
both cell–cell and cell–extracellular matrix interactions. They are involved in modifying …

It is 40 years since the first member of what came to be known as the matrix
metalloproteinase (MMP) family was described. Structural, molecular and biochemical …