4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only 

Brugada syndrome (BrS) is an inherited condition characterized by predisposition to
syncope and cardiac arrest, predominantly during sleep. The prevalence is∼ 1: 2,000, and 

This international multidisciplinary document intends to provide clinicians with evidence-
based practical patient-centered recommendations for evaluating patients and decedents 

Brugada syndrome (BrS) was first described as a primary electrical disorder predisposing to
the risk of sudden cardiac death and characterized by right precordial lead ST elevation 

Aims Genetic testing is recommended in specific inherited heart diseases but its role
remains unclear and it is not currently recommended in unexplained cardiac arrest (UCA) 

Brugada syndrome (BrS), early repolarization syndrome (ERS), and idiopathic ventricular
fibrillation (iVF) have long been considered primary electrical disorders associated with 

Idiopathic ventricular fibrillation is diagnosed in patients who survived a ventricular
fibrillation episode without any identifiable structural or electrical cause after extensive 

Ethnopharmacological relevance The plants are from the genus Rauvolfia Plum. ex
L.(Apocynaceae), which is represented by 74 species with many synonyms, and distributed 

The diagnosis of Brugada syndrome (BrS) requires the presence of a coved (Type 1) ST
segment elevation in the right precordial leads of the electrocardiogram (ECG). The dynamic 

Background Sodium channel blocker (SCB) infusion is used to unmask the
electrocardiographic pattern of Brugada syndrome. The test may also induce premature