Abstract The 4D Nucleome Network aims to develop and apply approaches to map the
structure and dynamics of the human and mouse genomes in space and time with the goal …

This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear
landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing …

Phase separation of multivalent protein and RNA molecules underlies the biogenesis of
biomolecular condensates such as membraneless organelles. In vivo, these condensates …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

The genome is partitioned into topologically associated domains and genomic
compartments with shared chromatin valence. This architecture is constrained by the DNA …

Symbiotic interactions were key to the evolution of chloroplast and mitochondria organelles,
which mediate carbon and energy metabolism in eukaryotes. Biological nitrogen fixation, the …

Sensory neurons in the mouse eye and nose have unusual chromatin organization. Here we
report their three-dimensional (3D) genome structure at 20-kilobase (kb) resolution …

Soft x-ray microscopy in the water window (∼ 285− 535 e V) is an emerging and unique tool
for 2D and 3D imaging of unstained intact cellular samples in their near-native state with few …

High-resolution and rapid imaging of host cell ultrastructure can generate insights toward
viral disease mechanism, for example for a severe acute respiratory syndrome coronavirus …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) has become
the preferred method for mapping chromatin accessibility due to its time and input material …