Electrical, contractile and structural remodeling during atrial fibrillation
M Allessie, J Ausma, U Schotten - Cardiovascular research, 2002 - academic.oup.com
The natural history of atrial fibrillation (AF) is characterized by a gradual worsening with time.
The recent finding that AF itself produces changes in atrial function and structure has …
The recent finding that AF itself produces changes in atrial function and structure has …
Crosstalk between calcium and redox signaling: from molecular mechanisms to health implications
Studies done many years ago established unequivocally the key role of calcium as a
universal second messenger. In contrast, the second messenger roles of reactive oxygen …
universal second messenger. In contrast, the second messenger roles of reactive oxygen …
Hypoxia. 4. Hypoxia and ion channel function
LA Shimoda, J Polak - American Journal of Physiology-Cell …, 2011 - journals.physiology.org
The ability to sense and respond to oxygen deprivation is required for survival; thus,
understanding the mechanisms by which changes in oxygen are linked to cell viability and …
understanding the mechanisms by which changes in oxygen are linked to cell viability and …
Transcript scanning reveals novel and extensive splice variations in human L-type voltage-gated calcium channel, Cav1. 2 α1 subunit
The L-type (Ca v 1.2) voltage-gated calcium channels play critical roles in membrane
excitability, gene expression, and muscle contraction. The generation of splice variants by …
excitability, gene expression, and muscle contraction. The generation of splice variants by …
Testosterone is a potent inhibitor of L-type Ca2+ channels
JL Scragg, RD Jones, KS Channer, TH Jones… - Biochemical and …, 2004 - Elsevier
Testosterone administration is beneficial in alleviating myocardial ischaemia in men with
significant coronary artery disease (CAD), a condition which is associated with …
significant coronary artery disease (CAD), a condition which is associated with …
Carbon monoxide: an emerging regulator of ion channels
WJ Wilkinson, PJ Kemp - The Journal of physiology, 2011 - Wiley Online Library
Carbon monoxide is rapidly emerging as an important cellular messenger, regulating a wide
range of physiological processes. Crucial to its role in both physiology and disease is its …
range of physiological processes. Crucial to its role in both physiology and disease is its …
Redox control of calcium channels: from mechanisms to therapeutic opportunities
LC Hool, B Corry - Antioxidants and Redox Signaling, 2007 - liebertpub.com
Calcium plays an integral role in cellular function. It is a well-recognized second messenger
necessary for signaling cellular responses, but in excessive amounts can be deleterious to …
necessary for signaling cellular responses, but in excessive amounts can be deleterious to …
Carbon monoxide inhibits L-type Ca2+ channels via redox modulation of key cysteine residues by mitochondrial reactive oxygen species
Conditions of stress, such as myocardial infarction, stimulate up-regulation of heme
oxygenase (HO-1) to provide cardioprotection. Here, we show that CO, a product of heme …
oxygenase (HO-1) to provide cardioprotection. Here, we show that CO, a product of heme …
Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles
An estimate of up to 60% of genes are subjected to alternative splicing, and 15% of human
genetic diseases are associated with mutation of the splice sites [Krawczak M, Reiss J, and …
genetic diseases are associated with mutation of the splice sites [Krawczak M, Reiss J, and …
Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels
EA Coppock, JR Martens… - American Journal of …, 2001 - journals.physiology.org
The hypoxia-induced membrane depolarization and subsequent constriction of small
resistance pulmonary arteries occurs, in part, via inhibition of vascular smooth muscle cell …
resistance pulmonary arteries occurs, in part, via inhibition of vascular smooth muscle cell …