One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …

The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …

Breast cancer and gliobalstoma are the most aggressive types of diseases causing serious
health issues. Potent anticancer molecules are facing serious side effects which arouse the …

Different vanillin‐based aldehydes were used to synthesize novel tetrahydropyrimidines
(THPMs) via conventional Biginelli reaction. The THPMs were tested against human normal …

Cancer is a complex disease that remains a leading cause of death worldwide owing to the
lack of effective and efficient drugs. Compounds known as tetrahydropyrmidine have shown …

New dihydropyrimidone scaffolds were synthesized by Biginelli reaction aiming minor
structural modifications of anti-cancer drug monastrol. The benzaldehyde part was chosen …

Regardless of the growing discovery of anticancer treatments targeting cancer-specific
pathways, cytotoxic therapy still maintained its abundant clinical significance because …

The aim of the presented research was to explore anticancer potential of eleven newly
synthesized tetrahydropyrimidine derivatives. The compounds were synthesized via Biginelli …

Green coffee bean extract (GCBE) captivated the world with its various health benefits.
However, its topical use was limited by the hampered penetration of hydrophilic GCBE …

Tetrahydropyrimidines have a fascinating scaffold that has garnered substantial attention
from pharmacists and medicinal chemists. They are heterocyclic compounds used in anti …