Recent advances in cancer fusion transcript detection

R Dorney, BP Dhungel, JEJ Rasko… - Briefings in …, 2023 - academic.oup.com
Extensive investigation of gene fusions in cancer has led to the discovery of novel
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …

Overcoming cancer drug-resistance calls for novel strategies targeting abnormal alternative splicing

J Zhang, X Xu, H Deng, L Liu, Y Xiang… - Pharmacology & …, 2024 - Elsevier
Abnormal gene alternative splicing (AS) events are strongly associated with cancer
progression. Here, we summarize AS events that contribute to the development of drug …

[PDF][PDF] 急性胰腺炎患者外周血lncRNA H19 表达与Th17/Treg 平衡的关系

徐晨, 何精选, 石珍, 徐鹏 - 临床急诊杂志, 2022 - lcjzen.whuhzzs.com
目的: 探究急性胰腺炎(AP) 患者外周血长链非编码RNA H19 (lncRNA H19) 表达与辅助性T
细胞17 (Th17)/调节性T 细胞(Treg) 平衡的关系. 方法: 以2019 年9 月—2021 年9 月收治的91 …

Functional and regulatory impact of chimeric RNAs in human normal and cancer cells

S Mukherjee, SB Mukherjee… - Wiley …, 2023 - Wiley Online Library
Fusions of two genes can lead to the generation of chimeric RNAs, which may have a
distinct functional role from their original molecules. Chimeric RNAs could encode novel …

Transcriptional regulation and its misregulation in human diseases

A Casamassimi, A Ciccodicola, M Rienzo - International Journal of …, 2023 - mdpi.com
Transcriptional regulation is a critical biological process that allows the cell or an organism
to respond to a variety of intra-and extracellular signals, to define cell identity during …

Ancient human endogenous retroviruses contribute to genetic evolution and regulate cancer cell type–specific gene expression

M Chen, L Jia, X Zheng, M Han, L Li, L Zhang - Cancer Research, 2022 - AACR
Human endogenous retroviruses (HERV), a type of transposable elements (TE), play crucial
roles in human placental morphogenesis, immune response, and cancer progression …

Identification and coregulation pattern analysis of long noncoding RNAs in the mouse brain after Angiostrongylus cantonensis infection

DH Cheng, TG Jiang, WB Zeng, TM Li, YD Jing, ZQ Li… - Parasites & …, 2024 - Springer
Background Angiostrongyliasis is a highly dangerous infectious disease. Angiostrongylus
cantonensis larvae migrate to the mouse brain and cause symptoms, such as brain swelling …

A novel tumor mutation-related long non-coding RNA signature for predicting overall survival and immunotherapy response in lung adenocarcinoma

W Chen, C Liao, X Xiang, H Li, Q Wu, W Li, Q Ma… - Heliyon, 2024 - cell.com
Background Immunotherapy has changed the treatment landscape for lung cancer. This
study aims to construct a tumor mutation-related model that combines long non-coding RNA …

Architects and Partners: The Dual Roles of Non-coding RNAs in Gene Fusion Events

R Dorney, L Reis-das-Mercês, U Schmitz - Computational Biology of Non …, 2024 - Springer
Extensive research into gene fusions in cancer and other diseases has led to the discovery
of novel biomarkers and therapeutic targets. Concurrently, various bioinformatics tools have …

Research progress on fusion genes in tumours

Y Chang, Z Zhao, Y Song - Clinical and Translational …, 2024 - Wiley Online Library
Background The concept of gene fusion describes the process of fusing two genes into one,
which is closely linked to tumour occurrence and development and may even be the direct …