J Zhang, X Xu, H Deng, L Liu, Y Xiang… - Pharmacology & …, 2024 - Elsevier
Abnormal gene alternative splicing (AS) events are strongly associated with cancer progression. Here, we summarize AS events that contribute to the development of drug …
Fusions of two genes can lead to the generation of chimeric RNAs, which may have a distinct functional role from their original molecules. Chimeric RNAs could encode novel …
Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra-and extracellular signals, to define cell identity during …
M Chen, L Jia, X Zheng, M Han, L Li, L Zhang - Cancer Research, 2022 - AACR
Human endogenous retroviruses (HERV), a type of transposable elements (TE), play crucial roles in human placental morphogenesis, immune response, and cancer progression …
Background Angiostrongyliasis is a highly dangerous infectious disease. Angiostrongylus cantonensis larvae migrate to the mouse brain and cause symptoms, such as brain swelling …
W Chen, C Liao, X Xiang, H Li, Q Wu, W Li, Q Ma… - Heliyon, 2024 - cell.com
Background Immunotherapy has changed the treatment landscape for lung cancer. This study aims to construct a tumor mutation-related model that combines long non-coding RNA …
R Dorney, L Reis-das-Mercês, U Schmitz - Computational Biology of Non …, 2024 - Springer
Extensive research into gene fusions in cancer and other diseases has led to the discovery of novel biomarkers and therapeutic targets. Concurrently, various bioinformatics tools have …
Y Chang, Z Zhao, Y Song - Clinical and Translational …, 2024 - Wiley Online Library
Background The concept of gene fusion describes the process of fusing two genes into one, which is closely linked to tumour occurrence and development and may even be the direct …