Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Both the basal body and the microtubule‐based axoneme it nucleates have evolutionarily
conserved subdomains crucial for cilium biogenesis, function and maintenance. Here, we …

The distal appendages (DAPs) of centrioles have been proposed to anchor cilia to the
plasma membrane, but their molecular composition, assembly, and exact function in …

Membrane association with mother centriole (M-centriole) distal appendages is critical for
ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary …

Centrioles are barrel-shaped structures that are essential for the formation of centrosomes,
cilia, and flagella. Here we review recent advances in our understanding of the function and …

In animal cells, the primary cilium transduces extracellular signals through signaling
receptors localized in the ciliary membrane, but how these ciliary membrane proteins are …

We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …

Cytotoxic T lymphocytes (CTLs) destroy virally infected and tumorigenic cells by releasing
the contents of specialized secretory lysosomes—termed 'lytic granules'—at the …

Centrosomes, which were first described in the late 19th century, are found in most animal
cells and undergo duplication once every cell cycle so that their number remains stable, like …

Cilia formation is a multi-step process that starts with the docking of a vesicle at the distal
part of the mother centriole. This step marks the conversion of the mother centriole into the …