SGLT2 inhibitor empagliflozin alleviates cardiac remodeling and contractile anomalies in a FUNDC1-dependent manner in experimental Parkinson's disease

W Yu, L Wang, W Ren, H Xu, NN Wu, D Yu… - Acta Pharmacologica …, 2024 - nature.com
Recent evidence shows a close link between Parkinson's disease (PD) and cardiac
dysfunction with limited treatment options. Mitophagy plays a crucial role in the control of …

Validating the anti-lymphoma pharmacodynamic actions of the endocannabinoids on canine non-Hodgkin lymphoma

S Omer, S Pathak, R Nadar, D Bowen, M Sandey… - Life Sciences, 2023 - Elsevier
Aims This study established the in vitro anti-lymphoma pharmacodynamic actions of the
endocannabinoids (anandamide—AEA and 2-arachidonoylglycerol—2AG) on canine non …

Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity

D Bhattacharya, A Fujihashi, M Majrashi, J Bloemer… - Heliyon, 2020 - cell.com
Aims This study investigated the neurotoxic effects of prenatal alcohol and nicotine exposure
in the cortex and hippocampus of rodents. Main methods Behavioral alterations …

Dopaminergic neurotoxic effects of 3-TFMPP derivatives

M Majrashi, M Almaghrabi, M Fadan, A Fujihashi… - Life sciences, 2018 - Elsevier
Designer drugs are synthetically formulated to mimic the psychostimulatory effects of an
original controlled/illegal drug of abuse. Designer drugs have similar chemical structure or …

Effects of Cannabidiol,∆ 9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines

S Omer, S Pathak, M Mansour, R Nadar, D Bowen… - Biomolecules, 2024 - mdpi.com
In our previous study, we demonstrated the impact of overexpression of CB1 and CB2
cannabinoid receptors and the inhibitory effect of endocannabinoids (2 …

Depressed contractile function and adrenergic responsiveness of cardiac myocytes in an experimental model of Parkinson disease, the MPTP-treated mouse

J Ren, JE Porter, LE Wold, NS Aberle II… - Neurobiology of …, 2004 - Elsevier
Radiotracer and biochemical studies have shown that patients with Parkinson disease lack
functional sympathetic innervation to the heart. The same observation was made in mice …

Evaluation of behavioral parameters, hematological markers, liver and kidney functions in rodents exposed to Deepwater Horizon crude oil and Corexit

S Ramesh, D Bhattacharya, M Majrashi, M Morgan… - Life sciences, 2018 - Elsevier
Abstract The 2010 Deepwater Horizon (DWH) oil spill is the largest marine oil spill in US
history. In the aftermath of the spill, the response efforts used a chemical dispersant, Corexit …

Effects of prenatal synthetic cannabinoid exposure on the cerebellum of adolescent rat offspring

PD Pinky, M Majrashi, A Fujihashi, J Bloemer… - Heliyon, 2021 - cell.com
Cannabis is the most commonly used illicit drug worldwide. Recently, cannabis use among
young pregnant women has greatly increased. However, prenatal cannabinoid exposure …

Apoptotic Mode of Cell Death in Substantia Nigra Following Intranigral Infusion of the Parkinsonian Neurotoxin, MPP+ in Sprague-Dawley Rats: Cellular, Molecular …

R Banerjee, S Sreetama, KS Saravanan, SN Dey… - Neurochemical …, 2007 - Springer
The potent parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
is known to cause dopaminergic neurodegeneration in nigrostriatal system. In the present …

[PDF][PDF] The levels of plasma IL-1beta, IL-6 of C57BL/6J mice treated with MPTP and brain lateralization

Y Luo, Y Su, Y Shen, L Zhao, K Li - Cell Mol. Immunol, 2004 - cmi.ustc.edu.cn
The work is to explore the relationship between the levels of cytokines (IL-1β and IL-6) in
C57BL/6J mice treated with MPTP and brain lateralization. By using paw preference test …