Proper control of Ca2+ signaling is mandatory for effective cell migration, which is critical for
embryonic development, wound healing, and cancer metastasis. However, how Ca2+ …

Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin
cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes …

The spectrin-based membrane skeleton is a ubiquitous membrane-associated two-
dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of …

Prostate cancer is responsible for over 30,000 US deaths annually, attributed largely to
incurable metastatic disease. Here, we demonstrate that high levels of plectin are …

Actin-cross-linking proteins assemble actin filaments into higher-order structures essential
for orchestrating cell shape, adhesion, and motility. Missense mutations in the tandem …

Stem cell loss causes tissue deterioration associated with aging. The accumulation of
genomic and oxidative stress-induced DNA damage is an intrinsic cue for stem cell loss,; …

This essay focuses on the role of plectin and its various isoforms in mediating intermediate
filament (IF) network functions. It is based on previous studies that provided comprehensive …

This protocol describes a workflow for creating structural models of proteins or protein
complexes using distance restraints derived from cross-linking mass spectrometry …

Abstract Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by
mutations in the cytoskeletal protein β-III-spectrin. Previously, a SCA5 mutation resulting in a …

Podocyte injury is an early pathological change characteristic of various glomerular
diseases, and apoptosis and F‐actin cytoskeletal disruption are typical features of podocyte …