The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …

Bacterial stress-signaling alarmones are important components of a protective network
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …

Timely adaptation to nutrient downshift is crucial for bacteria to maintain fitness during feast
and famine cycle in the natural niche. However, the molecular mechanism that ensures the …

Coupled transcription-translation (CTT) is a hallmark of prokaryotic gene expression. CTT
occurs when ribosomes associate with and initiate translation of mRNAs whose transcription …

Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …

Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the
effect of the microbiome on uric acid (UA) metabolism remains unclear. This study aimed to …

Bacteria are often exposed to long-term starvation during transportation and storage, during
which a series of enzymes and metabolic pathways are activated to ensure survival …

Under stressful growth conditions and nutrient starvation, bacteria adapt by synthesizing
signaling molecules that profoundly reprogram cellular physiology. At the onset of this …

The nucleotide messenger (p) ppGpp allows bacteria to adapt to fluctuating environments by
reprogramming the transcriptome. Despite its well-recognized role in gene regulation,(p) …

Two (p) ppGpp nucleotide analogs, sometimes abbreviated simply as ppGpp, are
widespread in bacteria and plants. Their name alarmone reflects a view of their function as …