Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …

Lectins and lectibodies: potential promising antiviral agents

M Nabi-Afjadi, M Heydari, H Zalpoor, I Arman… - Cellular & Molecular …, 2022 - Springer
In nature, lectins are widely dispersed proteins that selectively recognize and bind to
carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral …

A five-helix-based SARS-CoV-2 fusion inhibitor targeting heptad repeat 2 domain against SARS-CoV-2 and its variants of concern

L Xing, X Xu, W Xu, Z Liu, X Shen, J Zhou, L Xu, J Pu… - Viruses, 2022 - mdpi.com
The prolonged duration of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2) pandemic has resulted in the continuous emergence of variants of concern (VOC, eg …

Repurposing Navitoclax to block SARS‐CoV‐2 fusion and entry by targeting heptapeptide repeat sequence 1 in S2 protein

F Jiao, AM Andrianov, L Wang, KV Furs… - Journal of Medical …, 2023 - Wiley Online Library
Along with the long pandemic of COVID‐19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) has come the dilemma of emerging viral variants of concern …

Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein

A Nangarlia, FF Hassen, G Canziani, P Bandi… - Biochemistry, 2023 - ACS Publications
Host cell infection by SARS-CoV-2, similar to that by HIV-1, is driven by a conformationally
metastable and highly glycosylated surface entry protein complex, and infection by these …

The Effect of Select SARS-CoV-2 N-Linked Glycan and Variant of Concern Spike Protein Mutations on C-Type Lectin-Receptor-Mediated Infection

A Bains, W Guan, PJ LiWang - Viruses, 2023 - mdpi.com
The SARS-CoV-2 virion has shown remarkable resilience, capable of mutating to escape
immune detection and re-establishing infectious capabilities despite new vaccine rollouts …

Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor

N Cao, Y Cai, X Huang, H Jiang, Z Huang, L Xing, L Lu… - Mbio, 2024 - Am Soc Microbiol
Outbreaks of acute respiratory viral diseases, such as influenza and COVID-19 caused by
influenza A virus (IAV) and SARS-CoV-2, pose a serious threat to global public health …

[PDF][PDF] An enhanced broad-spectrum peptide inhibits Omicron variants in vivo

W Bi, K Tang, G Chen, Y Xie, NF Polizzi… - Cell Reports …, 2024 - cell.com
The continual emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants of concern (VOCs) poses a major challenge to vaccines and antiviral …

Construction and immune effect evaluation of the S protein heptad repeat-based nanoparticle vaccine against porcine epidemic diarrhea virus

D Yang, X Wang, X Yang, S Qi, F Zhao, D Guo, C Li… - Virology, 2024 - Elsevier
Porcine epidemic diarrhea virus (PEDV), a highly virulent enteropathogenic coronavirus, is a
significant threat to the pig industry. High frequency mutations in the PEDV genome have …

The Antiviral Activity of the Lectin Griffithsin against SARS-CoV-2 Is Enhanced by the Presence of Structural Proteins

A Bains, K Fischer, W Guan, PJ LiWang - Viruses, 2023 - mdpi.com
Although COVID-19 transmission has been reduced by the advent of vaccinations and a
variety of rapid monitoring techniques, the SARS-CoV-2 virus itself has shown a remarkable …