An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

The case for periodontitis in the pathogenesis of rheumatoid arthritis

J Potempa, P Mydel, J Koziel - Nature Reviews Rheumatology, 2017 - nature.com
Rheumatoid arthritis (RA), an autoimmune disease that affects∼ 1% of the human
population, is driven by autoantibodies that target modified self-epitopes, whereas∼ 11% of …

NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing

W Feng, JC Beer, Q Hao, IS Ariyapala… - Nature …, 2023 - nature.com
The blood proteome holds great promise for precision medicine but poses substantial
challenges due to the low abundance of most plasma proteins and the vast dynamic range …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

LA Borthwick - Seminars in immunopathology, 2016 - Springer
The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor
antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of …

Mast cells, neuroinflammation and pain in fibromyalgia syndrome

TC Theoharides, I Tsilioni, M Bawazeer - Frontiers in Cellular …, 2019 - frontiersin.org
Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain,
accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive …

IL-33/ST2 axis in autoimmune disease

L Shakerian, H Kolahdooz, M Garousi, V Keyvani… - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …

[HTML][HTML] Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective

S Salvioli, MS Basile, L Bencivenga, S Carrino… - Ageing Research …, 2023 - Elsevier
According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

TC Theoharides, JM Stewart, E Hatziagelaki… - Frontiers in …, 2015 - frontiersin.org
Brain “fog” is a constellation of symptoms that include reduced cognition, inability to
concentrate and multitask, as well as loss of short and long term memory. Brain “fog” …

Recent advances in our understanding of mast cell activation–or should it be mast cell mediator disorders?

TC Theoharides, I Tsilioni, H Ren - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …