Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

The mitochondrial network is not only required for the production of energy, essential
cofactors and amino acids, but also serves as a signaling hub for innate immune and …

Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …

Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …