Advances in sequencing technologies and increased access to sequencing services have
led to renewed interest in sequence and genome assembly. Concurrently, new applications …

2010 marks the 10th anniversary of the completion of the first plant genome sequence
(Arabidopsis thaliana). Triggered by advancements in sequencing technologies, many crop …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional
elements in the human genome sequence. The pilot phase of the Project is focused on a …

Comparisons of orthologous genomic DNA sequences can be used to characterize regions
that have been subject to purifying selection and are enriched for functional elements. We …

For over a decade, genome sequences have adhered to only two standards that are relied
on for purposes of sequence analysis by interested third parties (,). However, ongoing …

Giardia intestinalis is a major cause of diarrheal disease worldwide and two major Giardia
genotypes, assemblages A and B, infect humans. The genome of assemblage A parasite …

Background Comparative whole genome analysis of Mammalia can benefit from the
addition of more species. The pig is an obvious choice due to its economic and medical …

We present the first collection of tools aimed at automated genome assembly validation. This
work formalizes several mechanisms for detecting mis-assemblies, and describes their …

The ongoing generation of prodigious amounts of genomic sequence data from myriad
vertebrates is providing unparalleled opportunities for establishing definitive phylogenetic …