DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

Damage to DNA is generally considered to be a harmful process associated with aging and
aging-related disorders such as neurodegenerative diseases that involve the selective …

Oxidative stress promotes genomic instability and human diseases. A common oxidized
nucleoside is 8-oxo-7, 8-dihydro-2′-deoxyguanosine, which is found both in DNA (8-oxo …

Base damage or loss occurs at high frequency in the cells (almost 104 bases are damaged
and hydrolysed per cell per day). DNA repair is fundamental to maintain genomic integrity …

Radical oxygen species (ROS) generate various modified DNA bases. Among them 8-oxo-7,
8-dihydroguanine (8oxoG) is the most abundant and seems to play a major role in …

Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted
drugs, which has been a significant challenge in cancer management. With the growing …

trans-Resveratrol (3, 4′, 5-trihydroxystilbene; RES), a polyphenol found in particularly high
concentrations in red wine, has recently attracted intense interest for its potentially beneficial …

Mitochondrial DNA is constantly exposed to oxidative injury. Due to its location close to the
main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more …