Much has been learned in the past decades about molecular force generation. Single-
molecule techniques, such as atomic force microscopy, single-molecule fluorescence …

Given the unique biological requirements of sound transduction and the selective advantage
conferred upon a species capable of sensitive sound detection, it is not surprising that up to …

Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride
concentrations in surface water are low and fluorinated metabolites are extremely rare,. The …

When not transporting cargo, kinesin-1 is autoinhibited by binding of a tail region to the
motor domains, but the mechanism of inhibition is unclear. We report the crystal structure of …

The chemical kinetic mechanism of kinesin (K) is considered by using a consensus scheme
incorporating biochemically defined open, closed and trapped states. In the absence of …

Motor proteins couple steps in ATP binding and hydrolysis to conformational switching both
in and remote from the active site. In our kinesin• AMPPNP crystal structure, closure of the …

Members of the myosin superfamily are involved in all aspects of eukaryotic life. Their
function ranges from the transport of organelles and cargos to the generation of membrane …

Kinesin motors move on microtubules by a mechanism that involves a large, ATP-triggered
conformational change in which a mechanical element called the neck linker docks onto the …

We develop a mixed elastic network model (MENM) to study large‐scale conformational
transitions of proteins between two (or more) known structures. Elastic network potentials for …

Most kinesins move processively along microtubules by using energy derived from ATP
hydrolysis. Almost all of the intermediate structures of this ATPase reaction cycle have been …