Continuous and discontinuous RNA synthesis in coronaviruses
I Sola, F Almazán, S Zúñiga… - Annual review of …, 2015 - annualreviews.org
Replication of the coronavirus genome requires continuous RNA synthesis, whereas
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
Functional long-range RNA–RNA interactions in positive-strand RNA viruses
BL Nicholson, KA White - Nature Reviews Microbiology, 2014 - nature.com
Positive-strand RNA viruses are important human, animal and plant pathogens that are
defined by their single-stranded positive-sense RNA genomes. In recent years, it has …
defined by their single-stranded positive-sense RNA genomes. In recent years, it has …
The short-and long-range RNA-RNA interactome of SARS-CoV-2
The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the
etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA …
etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA …
Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription
CH Wu, PJ Chen, SH Yeh - Cell host & microbe, 2014 - cell.com
Coronaviruses contain a positive-sense single-stranded genomic (g) RNA, which encodes
nonstructural proteins. Several subgenomic mRNAs (sgmRNAs) encoding structural …
nonstructural proteins. Several subgenomic mRNAs (sgmRNAs) encoding structural …
Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform
Emerging and re-emerging zoonotic viral diseases are major threats to global health,
economic stability, and national security. Vaccines are key for reducing coronaviral disease …
economic stability, and national security. Vaccines are key for reducing coronaviral disease …
Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses
K Bentley, SM Keep, M Armesto, P Britton - Journal of virology, 2013 - Am Soc Microbiol
Coronavirus subgenomic mRNA (sgmRNA) synthesis occurs via a process of discontinuous
transcription involving transcription regulatory sequences (TRSs) located in the 5′ leader …
transcription involving transcription regulatory sequences (TRSs) located in the 5′ leader …
m6A Methylation of Transcription Leader Sequence of SARS‐CoV‐2 Impacts Discontinuous Transcription of Subgenomic mRNAs
MA Becker, N Meiser… - … A European Journal, 2024 - Wiley Online Library
The SARS‐CoV‐2 genome has been shown to be m6A methylated at several positions in
vivo. Strikingly, a DRACH motif, the recognition motif for adenosine methylation, resides in …
vivo. Strikingly, a DRACH motif, the recognition motif for adenosine methylation, resides in …
Global organization of a positive-strand RNA virus genome
B Wu, J Grigull, MO Ore, S Morin, KA White - PLoS pathogens, 2013 - journals.plos.org
The genomes of plus-strand RNA viruses contain many regulatory sequences and structures
that direct different viral processes. The traditional view of these RNA elements are as local …
that direct different viral processes. The traditional view of these RNA elements are as local …
Long-distance RNA-RNA interactions in the coronavirus genome form high-order structures promoting discontinuous RNA synthesis during transcription
PA Mateos-Gomez, L Morales, S Zuñiga… - Journal of …, 2013 - Am Soc Microbiol
Coronavirus (CoV) transcription requires a high-frequency recombination process that links
newly synthesized minus-strand subgenomic RNA copies to the leader region, which is …
newly synthesized minus-strand subgenomic RNA copies to the leader region, which is …
Thermal inactivation of COVID‐19 specimens improves RNA quality and quantity
The rapid spread of coronavirus disease 2019 (COVID‐19), a disease caused by severe
acute respiratory syndrome coronavirus 2, poses a huge demand for immediate diagnosis …
acute respiratory syndrome coronavirus 2, poses a huge demand for immediate diagnosis …