The Role of (E)-β-Farnesene in Tritrophic Interactions: Biosynthesis, Chemoreception, and Evolution

B Wang, E Jacquin-Joly, G Wang - Annual Review of …, 2024 - annualreviews.org
(E)-β-farnesene (EBF) stands out as a crucial volatile organic compound, exerting significant
influence on the complex interactions between plants, aphids, and predator insects. Serving …

Olfactory receptors as an emerging chemical sensing scaffold

A Patel, P Peralta-Yahya - Biochemistry, 2022 - ACS Publications
Chemical biosensors are an increasingly ubiquitous part of our lives. Beyond enzyme-
coupled assays, recent synthetic biology advances now allow us to hijack more complex …

Transport features predict if a molecule is odorous

EJ Mayhew, CJ Arayata, RC Gerkin… - Proceedings of the …, 2022 - National Acad Sciences
In studies of vision and audition, stimuli can be chosen to span the visible or audible
spectrum; in olfaction, the axes and boundaries defining the analogous odorous space are …

Metabolic activity organizes olfactory representations

WW Qian, JN Wei, B Sanchez-Lengeling, BK Lee… - Elife, 2023 - elifesciences.org
Hearing and vision sensory systems are tuned to the natural statistics of acoustic and
electromagnetic energy on earth and are evolved to be sensitive in ethologically relevant …

M2OR: a database of olfactory receptor–odorant pairs for understanding the molecular mechanisms of olfaction

M Lalis, M Hladiš, SA Khalil, L Briand… - Nucleic Acids …, 2024 - academic.oup.com
Mammalian sense of smell is triggered by interaction between odorant molecules and a
class of proteins, called olfactory receptors (ORs). These receptors, expressed at the surface …

Artificial intelligence uncovers carcinogenic human metabolites

A Mittal, SK Mohanty, V Gautam, S Arora… - Nature Chemical …, 2022 - nature.com
The genome of a eukaryotic cell is often vulnerable to both intrinsic and extrinsic threats
owing to its constant exposure to a myriad of heterogeneous compounds. Despite the …

Application of artificial intelligence to decode the relationships between smell, olfactory receptors and small molecules

R Achebouche, A Tromelin, K Audouze… - Scientific reports, 2022 - nature.com
Deciphering the relationship between molecules, olfactory receptors (ORs) and
corresponding odors remains a challenging task. It requires a comprehensive identification …

Advancing chemical carcinogenicity prediction modeling: opportunities and challenges

A Mittal, G Ahuja - Trends in Pharmacological Sciences, 2023 - cell.com
Carcinogenicity assessment of any compound is a laborious and expensive exercise with
several associated ethical and practical concerns. While artificial intelligence (AI) offers …

Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular–Kidney–Metabolic Axis

MR Beito, S Ashraf, D Odogwu, R Harmancey - Life, 2024 - mdpi.com
Olfactory receptors (ORs) represent one of the largest yet least investigated families of G
protein-coupled receptors in mammals. While initially believed to be functionally restricted to …

Geruchsintensive Stoffe: Grundlagen, Bewertung und Markierung

C Van Thriel, C Monsé, AW Rettenmeier… - The MAK Collection for …, 2023 - zora.uzh.ch
1 Hintergrund Seit der Veröffentlichung der MAK-und BAT-Werte-Liste 2021 (DFG 2021)
wird durch die Vergabe einer Fußnote („Auch bei Einhaltung des MAK-Wertes sind im …