The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
Akt: a key transducer in cancer
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
Copper promotes tumorigenesis by activating the PDK1‐AKT oncogenic pathway in a copper transporter 1 dependent manner
Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human
tumorigenesis is not well defined. Here, it is revealed that copper activates the …
tumorigenesis is not well defined. Here, it is revealed that copper activates the …
A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1
Abstract Background The RTK/PI3K/AKT pathway plays key roles in the development and
progression of many cancers, including GBM. As a regulatory molecule and a potential drug …
progression of many cancers, including GBM. As a regulatory molecule and a potential drug …
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
The serine/threonine kinase Akt plays a central role in cell proliferation, survival and
metabolism, and its hyperactivation is linked to cancer progression. Here we report that Akt …
metabolism, and its hyperactivation is linked to cancer progression. Here we report that Akt …
The Skp2 pathway: a critical target for cancer therapy
Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for
various cellular processes whose dysregulation is linked to serious diseases including …
various cellular processes whose dysregulation is linked to serious diseases including …
PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
AKT is involved in a number of key cellular processes including cell proliferation, apoptosis
and metabolism. Hyperactivation of AKT is associated with many pathological conditions …
and metabolism. Hyperactivation of AKT is associated with many pathological conditions …
SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions
Q Jiang, N Zheng, L Bu, X Zhang, X Zhang, Y Wu… - Molecular Cancer, 2021 - Springer
Background 3-phosphoinositide-dependent protein kinase-1 (PDK1) acts as a master
kinase of protein kinase A, G, and C family (AGC) kinase to predominantly govern cell …
kinase of protein kinase A, G, and C family (AGC) kinase to predominantly govern cell …
[HTML][HTML] SETDB1 in cancer: overexpression and its therapeutic implications
VJ Lazaro-Camp, K Salari, X Meng… - American journal of …, 2021 - ncbi.nlm.nih.gov
Abstract SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1, ESET,
KMT1E) is a H3K9 methyltransferase involved in gene silencing. In recent years, SETDB1 …
KMT1E) is a H3K9 methyltransferase involved in gene silencing. In recent years, SETDB1 …
Histone methyltransferase SETDB1: a common denominator of tumorigenesis with therapeutic potential
Epigenetic regulation of gene expression has been ultimately linked to cancer development,
with posttranslational histone modifications representing attractive targets for disease …
with posttranslational histone modifications representing attractive targets for disease …