Synthesis of some azoles incorporating a sulfonamide moiety as anticonvulsant agents

AA Farag, SN Abd‐Alrahman, GF Ahmed… - Archiv der …, 2012 - Wiley Online Library
Many derivatives of heterocyclic compounds containing a sulfonamide thiazole moiety were
synthesized through the reaction of 2‐(cyano or chloro)‐N‐(4‐(N‐thiazol‐2‐ylsulfamoyl) …

Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4, 5-diphenyl-2H-1, 2, 4-triazol-3 (4H)-one

M Shalini, P Yogeeswari, D Sriram… - Biomedicine & …, 2009 - Elsevier
A new series of 4, 5-diphenyl-2H-1, 2, 4-triazol-3 (4H)-one were synthesized to study the
effect of cyclization of the semicarbazone moiety of aryl semicarbazones on the …

Semicarbazone analogs as anticonvulsant agents: a review

M Jawed Ahsan - Central Nervous System Agents in Medicinal …, 2013 - ingentaconnect.com
Semicarbazones are synthesized by the condensation of semicarbazide and
aldehyde/ketone. The literature survey revealed that semicarbazones had been emerged as …

Design, synthesis, and anticonvulsant evaluation of some novel 1, 3 benzothiazol-2-yl hydrazones/acetohydrazones

P Kumar, B Shrivastava, SN Pandeya, L Tripathi… - Medicinal Chemistry …, 2012 - Springer
Abstract A series of 2-[2-(substituted) hydrazinyl]-1, 3-benzothiazole and 2-(1, 3-
benzothiazol-2-ylsulfanyl)-N′-(substituted) acetohydrazide were designed and synthesized …

Design & synthesis of 2-(substituted aryloxy)-5-(substituted benzylidene)-3-phenyl-2, 5-dihydro-1H-[1, 2, 4] triazin-6-one as potential anticonvulsant agents

D Kaushik, SA Khan, G Chawla - European journal of medicinal chemistry, 2010 - Elsevier
A series of 2-(substituted aryloxy)-5-(substituted benzylidene)-3-phenyl-2, 5-dihydro-1H-[1,
2, 4] triazin-6-one were designed & synthesized using appropriate synthetic route keeping in …

1, 5-Disubstituted-1, 2, 3-Triazoles as GABA analogues: Synthesis, QSAR and biological evaluation as Pseudomonas fluorescens GABA-AT inhibitors

L Díaz-Peralta, M Fernandez-Zertuche… - Tetrahedron, 2024 - Elsevier
We report the synthesis of a new series of γ-aminobutyric acid (GABA) analogues as
possible GABA-AT inhibitors, where the nitrogen at the Ƴ-position is contained in a 1, 5 …

Synthesis of N1-(3-chloro-4-flourophenyl)-N4-substituted semicarbazones as novel anticonvulsant agents

M Amir, MJ Ahsan, I Ali - 2010 - nopr.niscpr.res.in
Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in
three steps involving aryl urea and aryl semicarbazide formation. The structures have been …

QSAR and molecular docking studies of the inhibitory activity of novel heterocyclic GABA analogues over GABA-AT

J Rodríguez-Lozada, E Tovar-Gudiño… - Molecules, 2018 - mdpi.com
We have previously reported the synthesis, in vitro and in silico activities of new GABA
analogues as inhibitors of the GABA-AT enzyme from Pseudomonas fluorescens, where the …

Novel-Substituted Heterocyclic GABA Analogues. Enzymatic Activity against the GABA-AT Enzyme from Pseudomonas fluorescens and In Silico Molecular Modeling

E Tovar-Gudiño, JA Guevara-Salazar… - Molecules, 2018 - mdpi.com
γ-Aminobutyric acid (GABA) is the most important inhibitory neurotransmitter in the central
nervous system, and a deficiency of GABA is associated with serious neurological disorders …

One-pot synthesis of some new semicarbazone, thiosemicarbazone, and hydrazone derivatives of 1-phenyl-3-arylpyrazole-4-carboxaldehyde from acetophenone …

R Pundeer, P Ranjan, K Pannu… - Synthetic …, 2008 - Taylor & Francis
Abstract Semicarbazone derivatives 3 of 1, 3-diphenylpyrazole-4-carboxaldehyde have
been synthesized in high yields through a one-pot procedure involving acetophenone …