This brief review summarizes current evidence regarding lower extremity peripheral artery
disease (PAD) and lower extremity skeletal muscle pathology. Lower extremity ischemia is …

Background Exercise programmes are a relatively inexpensive, low‐risk option compared
with other, more invasive therapies for treatment of leg pain on walking (intermittent …

Peripheral artery disease (PAD) affects more than 200 million adults worldwide. Patients
with lower extremity PAD have a heightened risk for cardiovascular events because of the …

Peripheral artery disease (PAD) is due to the blockage of the arteries supplying blood to the
lower limbs usually secondary to atherosclerosis. The most severe clinical manifestation of …

Background Patients with lower extremity peripheral arterial disease (PAD) and sarcopenia
are a population at risk requiring specific and targeted care. The aim of this review is to …

Walking exercise is the most effective noninvasive therapy that improves walking ability in
peripheral artery disease (PAD). Biologic mechanisms by which exercise improves walking …

Peripheral arterial disease (PAD) leads to chronic vascular occlusion and results in end
organ damage in critically perfused limbs. There are currently no clinical methods available …

Peripheral artery disease (PAD) is caused by atherosclerosis in the lower extremities, which
leads to a spectrum of life-altering symptomatology, including claudication, ischemic rest …

Maintenance of skeletal muscle mass and function is an incredibly nuanced balance of
anabolism and catabolism that can become distorted within different pathological conditions …

Rationale: Klf (kruppel-like factor) 2 is critical to establish and maintain endothelial integrity.
Objective: Therefore, determining upstream and downstream mediators of Klf2 would lead to …