Platelets have traditionally been viewed as fragmentary mediators of coagulation. However,
recent molecular and cellular evidence suggests that they have multiple roles in host …

Morbidity and mortality from venous thromboembolism (VTE), which refers to deep vein
thrombosis and pulmonary embolism, have a substantial effect on the global burden of …

Discussion Taking all these various pieces of evidence (albeit minimal), we would like to
hypothesize that in COVID-19 patients, IL-17A could potentially promote a pro-thrombotic …

In addition to being recognized as a chronic inflammatory disease that manifests in the skin,
psoriasis is increasingly understood to be a systemic disease that causes immune …

Platelets are currently acknowledged as cells of innate immunity and inflammation and play
a complex role in sepsis. We examined whether different types of LPS have different effects …

Parkinson's disease (PD) is a well-known neurodegenerative disease with a strong
association established with systemic inflammation. Recently, the role of the gingipain …

Recent advances in immunology enabled the characterization of several signal transmitting
pathways responsible for proper cytokine and chemokine signaling. Among them, Janus …

Th cells are the major effector cells in transplant rejection and can be divided into Th1, Th2,
Th17, and Treg subsets. Th differentiation is controlled by transcription factor expression …

Atherosclerosis is an inflammatory disease with break-down of homeostatic immune
regulation of vascular tissues. As a critical initiator of host immunity, dendritic cells (DCs) …

Rheumatoid arthritis (RA) is mainly caused by joint inflammation. RA significantly increases
the probability of cardiovascular disease. Although the progress of RA has been well …