The capacity of pancreatic β-cells to adapt to insulin resistance is crucial for glucose
homeostasis and is a factor in the development of type 2 diabetes. The insulin receptor …

Converging evidence from the analysis of human brain tumors and genetically engineered
mice has revealed that the mammalian target of rapamycin (mTOR) pathway is a central …

BACKGROUND & AIMS: Extensive evidence suggests that Akt signaling plays an important
role in β-cell mass and function, although its function in the regulation of the different …

To study the role of the neurofibromatosis-1 (NF1) gene in mammalian brain development,
we recently generated mice in which Nf1 gene inactivation occurs in neuroglial progenitor …

During mouse embryonic development, vasculogenesis initially occurs in the yolk sac,
preceding neurulation. Our previous studies have demonstrated that maternal diabetes …

Cre/loxP‐dependent expression of fluorescent proteins represents a powerful biological tool
for cell lineage, fate‐mapping, and genetic analysis. Live tissue imaging has significantly …

Background Multicellular organisms are characterized by a remarkable diversity of
morphologically distinct and functionally specialized cell types. Transgenic techniques for …

Abstract The Cullin 4A (Cul4A) gene is important in cell survival, development, growth, and
cell cycle control and is amplified in breast and hepatocellular cancers. Recently, we …

31. Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J,
Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen …

31. Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J,
Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen …