The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family,
binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express …

The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

Five unrelated children are described with a rare autoimmune lymphoproliferative syndrome
(ALPS) characterized by massive nonmalignant lymphadenopathy, autoimmune …

Chemotherapeutic drugs cause DNA damage and kill cancer cells mainly by apoptosis. p53
mediates apoptosis after DNA damage. To explore the pathway of p53-dependent cell …

Fas/APO-1 is a cell surface protein known to trigger apoptosis upon specific antibody
engagement. Because wild-type p53 can activate transcription as well as induce apoptosis …

Interferons are a family of cytokines that exerts antiviral, antitumor and immunomodulatory
actions by inducing a complex set of proteins. One of the best known IFN-induced protein is …

The dsRNA‐dependent protein kinase (PKR) is considered to play a key role in interferon‐
mediated host defense against viral infection and conceivably malignant transformation. To …

Background The Canale–Smith syndrome is a childhood disorder characterized by
lymphadenopathy and autoimmunity. The similarity between this syndrome and that in mice …